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Conference presentation

Presentation at the IFSCC International Congress

Award-winning study: Top award at the 20th IFSCC (International Federation of Societies of Cosmetic Chemists) International Congress Mystery of the Deep Part of the Skin: State of the Art Skin Science–Skin Produce Theory

The skin-Produce Theory proposes for the first time in the world a new approach for the improvement of aging–collagen remodeling.


Cutaneous Drug Research Laboratories
Yasutomo Nishimori, Ph.D.

What is the Skin-Produce Theory?

Collagen, accounting for approximately 80% of the dermal components of the skin, has a structure like a rope, a bundle of many fibers. The fibers are woven like a bundle in the skin not exposed to ultraviolet light, while bundles of fibers are broken in the skin exposed to ultraviolet light, even if it is the skin of young people and has a high collagen level. This is the state of aging of the dermis caused by ultraviolet light. We decided that not only increase in collagens but also remodeling of a broken collagen fiber structure is the most effective way of improving aged dermis. This is the Skin-Produce Theory.

Example of application of the theory

We focused all our energy on finding materials that can remodel collagen fiber structures, and we extracted various plant extracts said to be effective for the skin by various extract methods, and the efficacy of each was evaluated. We used more than a few hundred species of plants in our experiments. Five years had passed by, when we discovered that a certain western herb extract extracted by a specific method had the efficacy we targeted. We called the extract “plant energy extract” and succeeded in containing it in cosmetic products together with other components, which increase collagens.

Images of recovery of the skin

Collagen decreases and fiber bundle structure is broken.


Collagen increases and fiber bundle structure begins to recover.


Fiber bundle structure is made of firm bundles of many collagens.

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