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Presentations at the IFSCC International Conference

The R&D Center of the POLA Chemical industries, Inc. presented two academic papers
at the 23rd IFSCC International Conference in Zurich.

The R&D Center of the POLA Chemical Industries, Inc. presented the following two academic papers at the 23rd IFSCC International Conference in Zurich (September 21-23, 2015).

The two articles presented at the conference by the POLA Chemical Industries, Inc. included one oral and one poster presentation. Here are the two presentations.

At the 23rd IFSCC Conference, the study of "Breakthrough in improving the skin sagging with focusing on the subcutaneous tissue structure, retinacula cutis" won the best award in the Basic Research category (Oral).

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1. Breakthrough in improving the skin sagging with focusing on the subcutaneous tissue structure, retinacula cutis

Pronounced sagging of the facial skin is a major skin concern from middle age onwards; however, many aspects of the underlying mechanism remain unknown. Recent studies have clarified that aging affects not only the skin but also the structure of the subcutaneous tissue, and sagging treatments targeting the subcutaneous tissue are being actively pursued in the field of cosmetic medicine. Magnetic resonance imaging (MRI) provides a visual representation of the inside of the body. The present study used MRI to examine the retinacula cutis (RC), a net-like fibrous structure that extends throughout the subcutaneous tissue, and investigated its relationship with sagging of the facial skin. The following results were obtained. 1) MRI enabled visualization of the RC without damaging the skin. 2) The degree of sagging tended to be greater in areas of lower RC density, demonstrating a correlation between RC density and elasticity of the lower layers of the skin. Thus, thinning of the net-like structure of the RC decreases the elasticity of the subcutaneous tissue, likely causing sagging. The presenting findings demonstrated that MRI can be used to non-invasively visualize the RC inside the subcutaneous tissue of the face and identified the RC as a potential target for sagging treatment.

 

Dermatological R&D
Skin Research Department
Aya Sakata

2.Versican: a potent player for anti-aging skin care by compensating loss of sex-hormone effects

Wrinkles, sagging, and other signs of skin aging associated with decreased elasticity become more pronounced in women as menopause approaches and continue to increase after menopause. The present study focused on age- and menopause-related changes in women’s skin, and the following results were obtained. 1) Expression levels of collagen, elastin, and versican, a proteoglycan that is known to be the third major component of the skin, decreased with age. 2) Versican was regulated by the sex hormone 17β-estradiol. 3) Versican appeared to contribute to skin elasticity. These findings suggest that decreased levels of sex hormones in menopausal women lead to decreased expression of versican in the skin, causing skin aging. Application of the obtained findings may enable the reversal of skin aging, an achievement that has eluded conventional anti-aging care targeting collagen and elastic fibers.

 

Dermatological R&D
Skin Research Department
Hirotaka Takeuchi

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