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Presentations at the IFSCC International Congress

The R&D Center of the POLA Chemical Industries, Inc. presented four academic papers at the 22nd IFSCC International Congress in Edinburgh.

The R&D Center of the POLA Chemical Industries, Inc. presented the following four academic papers at the 22nd IFSCC International Congress in Edinburgh (September 2002).

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1. Improvement of Collagen Fiber Bundle Structure Damaged by Photoaging Focusing on Interaction of Fibroblasts and Fibronectins (Oral Presentation)

We reported at the 20th IFSCC International Congress that remodeling of collagen fiber bundles was important in the improvement of photoaged skin. In the present study, we further tried to elucidate the mechanism by which the collagen fiber bundle structure is destroyed by photoaging. We focused on fibroblasts, which play an important role in the rearrangement of collagen fibers and found that interaction of fibroblasts and fibronectins (extracellular matrix protein) was important. Evaluation of materials to be improved, using test systems established in the course of our study, showed the efficacy of eugenol. It was elucidated that eugenol inhibited accumulation of type-I collagen and glycosaminoglycan and enhanced adhesion of fibroblasts and fibronectins to improve collagen fiber bundle structure damaged by photoaging.


Hair&Skin Care Products R&D Department
Akihiro Tada

2. Non-Invasive Evaluation of Superficially Invisible Skin Damage by Ultraviolet (Oral Presentation)

The internal structure of the skin changes by continuous ultraviolet radiation, resulting in wrinkles on the surface of the skin. There is a higher possibility that the skin damage could be improved with agents or cosmetic products at early stages of mild ultraviolet-induced damage because of the self-repairing ability of the skin. However, damage by ultraviolet light appears on the surface only when it becomes severe, and the skin has to be collected to see the internal changes during the early stage. We reported in the IFSCC in 1998 that wrinkles and skin's elasticity were improved by recovery of dermal collagen fiber bundle (DCFB) structure changed by ultraviolet light. In the present study, using DCFB as an index of damage by ultraviolet light, we examined a method to detect the damage without collection of skin samples. Finally, we found that measurements of the resiliometer we developed were correlated with the state of DCFB, suggesting that the state of DCFB could be detected by noninvasively measuring the dynamic properties of the skin by the resiliometer.


Cosmetic Value Creation R&D Department
Ai Oba

3. Effects of Cosmetic Vehicle on Atopic Dermatitis (Poster Presentation)

The global trend of cosmetics is cosmeceutical, and application of highly effective components to cosmetic products is required. On the other hand, it should be remembered that a simple skin-care vehicle that does not contain active ingredients can keep the skin normal. Here, we examined how effectively a skin-care vehicle works on atopic dermatitis characterized by dry skin and skin itch, which has a lot of influence over makeup behaviors of consumers. In the present study, the skin-care preparation was applied on the skin model of atopic dermatitis and changes on the surface of the skin and in the state of inflammation of the inside were observed. The results indicated that the state of the skin surface significantly improved and that the state of the inside of the skin also partly improved. Therefore, even a simple skin-care preparation would be enough to contribute to improvement of atopic dermatitis.


Cutaneous Drug Research Laboratories
Katsuo Matsumoto

4. Development of a New Cosmetic Polymer with Barrier Function against Stimulants

There are numerous chemical substances in the living environment surrounding us. Sometimes, these chemical substances cause feelings of stimulation, which is harmful to the skin. The feeling of stimulation of the skin is a phenomenon generated by permeation of chemical substances dissolved into water and oils. Based on this mechanism, we conceived a strategy to protect the body from feelings of stimulation, that is, a material that can form membrane-blocking carriers of chemical substances, oils, and water. We finally succeeded in developing a new material, FPA copolymer. The material is skin-friendly and well miscible with other cosmetic components, so that it can be applied in a wide range of products. A test on the feeling of stimulation, performed with 18 participants, showed that cosmetic products containing FPA copolymer significantly inhibited the feeling of stimulation compared with those without FPA copolymer.


Makeup and Fragrance Products R&D Department
Ayako Kuroda

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