Top page > Research > Study results > Conference presentation > The 25th IFSCC International Congress in Barcelona

Research

Study results

Conference presentation

Presentations at the IFSCC International Congress

The R&D Center of the POLA Chemical Industries, Inc. presented four academic papers at the 25th IFSCC International Congress in Barcelona.

The R&D Center of the POLA Chemical Industries, Inc. presented the following four academic papers at the 25th IFSCC International Congress in Barcelona (October 6–9, 2008).

The four articles presented at the congress by the POLA Chemical Industries, Inc. included two oral and two poster presentations. Only papers that passed a rigorous screening were allowed to be presented as an oral presentation. Here are the four presentations (titles only for two poster presentations). At the 25th IFSCC Congress, the study of “Epidermal Tight Junction: The Master Skin Barrier Regulator” won the top award in the category of basic research. See the following link on news releases.

| Back | 1 | 2 | 3 | 4 |

1. Epidermal Tight Junction: The Master Skin Barrier Regulator

POLA has focused on the formation of a healthy stratum corneum for many years because it is a very important factor for healthy, beautiful skin. Two factors, distribution of calcium ions in the epidermis under the stratum corneum and secretion of an intercellular lipid component, are said to be the key for the formation of a normal stratum corneum. Assuming that tight junction (TJ) structure existing in the upper epidermis plays a role in regulating those two factors, POLA is now conducting studies with epidermal cells and cultured skin models. To date, we have TJs that are likely to be involved in concentration-gradient formation of epidermal calcium, which is the first key factor for the formation of the stratum corneum, as calcium ion movement is not normally regulated in the skin when TJ function declines. TJs are also found to be involved in the second factor, the secretion of an intercellular lipid component. In the present study, we found by experiments using epidermal cells and cultured skin models that when TJ function declines, prolamellar bodies and ceramides in the skin are not normally secreted; that is, TJs are involved in two important factors for the formation of a healthy stratum corneum. It was also found that TJs can function as a barrier to excess moisture loss in the skin, indicating that TJs might be the behind-the-scenes architect for healthy and beautiful skin. We hope that it will contribute to the progress of dermatology and be applied in the skin-care field.

 

Cutaneous Drug Research Department
Shohei Kuroda

2. Enhancement of Skin Barrier Function by a Lotion Containing 1% Ceramide 2

Ceramide is a principal component of the stratum corneum intercellular lipid (lamella structure), which plays an important role in water retention in the stratum corneum of the skin. However, ceramide cannot be stably preserved, especially in a lotion, because of its extremely low solubility, and it has been considered to be technically difficult to be positively incorporated into cosmetic lotions. Therefore, ceramides have been mainly incorporated in moisturizing cream.
According to a questionnaire survey of 96 females aged 20–49, lotion was used by 95% of them, but cream was less used because of its sticky texture. We then thought that if ceramides could be included in lotions, the high value-added lotions would meet market needs. In the present study, we swelled only the hydrophilic site of lamella structure formed mainly with ceramides with an ionic surfactant and succeeded in generating transparent capsular particles. We then identified in a study using a cultured skin model that particles with a very small particle size of 40 nm are highly permeable. When the lotion was applied on artificial rough skin, its barrier function against moisture loss was found to be comparatively higher than that of a general moisturizer, glycerin. The study results show a new value added to lotion products, that is, application of a lotion containing 1% ceramide can improve the skin-barrier function and moisture-retaining ability of the epidermis.

 

Skin Care Products R&D Department
Hidetaka Akatsuka

3. Developing Make-up Foundation Specifically for Elderly Women and Measuring Effectiveness Using EEG Analysis

4. Advanced Glycation End Products Crosslinks Breaker : A New Approach for Improvement of Aged Skin

Conference presentation←Back  
Website policy  |  Handling of personal information  |  Site map