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Conference presentation

Presentations at the IFSCC International Congress

The R&D Center of the POLA Chemical Industries, Inc. presented three academic papers at the 27th IFSCC International Congress in Johannesburg.

The R&D Center of the POLA Chemical Industries, Inc. presented the following three academic papers at the 27th IFSCC International Congress in Johnnesburg (October 15–18, 2012).

The three articles presented at the congress by the POLA Chemical Industries, Inc. included one oral and two poster presentations. Here are the three presentations. At the 27th IFSCC Congress, the study of “Identification and Mechanisms of Adrenomedullin as a Novel Melanocyte-Activating Factor” won the best award in the category of poster presentation.

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1. Improvement of Chronological Skin Aging through Autophagy Regulation (Oral Presentation)

There have been numerous reports on the mechanisms of skin aging, most of which have focused on sun-induced skin aging (photoaging). However, skin also undergoes chronological aging, similarly to other organs. Here, we examined the involvement of the age-dependent change of autophagy, a highly conserved cellular degradation process, in chronological skin aging. We found that autophagy was disrupted at the later phase in elderly skin taken from sun-protected areas, which leads to accumulation of autophagy-specific structures. Moreover, inhibition of the latter phase in autophagy by lysosomal protease inhibitors induced the breakdown of collagen fibrils, reduced collagen, hyaluronan, and elastin levels, and increased MMP-1 expression. Our findings suggest that autophagy disruption is an important factor inducing the age-dependent skin changes.
We conclude that the cosmetic approach to autophagy regulation would enable us to reverse chronological changes within skin, providing consumers with new insights into the potential of anti-aging skincare.


Dermatological R&D
Skin Research Department
Kanae Tashiro

2. Identification and Mechanisms of Adrenomedullin as a Novel Melanocyte-Activating Factor (Poster Presentation)

Abnormal melanin accumulation can cause the areas of uneven pigmentation. Many studies have focused on intracellular melanin synthesis, and the resulting discoveries have led to the development of various cosmetics. However, these products do not show a high degree of efficacy. This suggests the existence of unknown factors beyond our current understanding of the mechanisms underlying melanin accumulation. We focused on dendrites, based on their role as the primary cell structure responsible for melanin transport in melanocytes. Few dendrites are seen under steady-state culture conditions, but activated melanocytes show increased numbers of dendrites, augmenting the area of melanin distribution. We assumed that this morphological change plays a pivotal role in melanin accumulation. In this study, we carried out an exhaustive analysis to identify new factors related to numbers of dendrites. Adrenomedullin (ADM) was identified as a novel melanocyte-activating factor. ADM markedly increased the number of dendrites and also stimulated melanin synthesis. Higher levels of ADM were detected in pigmented lesions and UV-irradiated lesions in human skin. ADM is thus considered to be a key factor in melanin accumulation.


Dermatological R&D
Skin Research Department
Tomonori Motokawa

3. Objective Evaluation of Our Aging Faces: An Integrated Approach through Spatial Frequency Analysis (Poster Presentation)

The impression of facial apparent age in human is different even if they are the same age. Our current measurement technologies allow us to analyze various parameters of facial aging. Although such measurements are useful, they are not sufficiently accurate for assessing the apparent age since these can evaluate the individual parts in the face but not entire. Therefore, an integrated evaluation approach is needed to account for all significant factors in entire face that influence our visual judgment of apparent age.
In this study, spatial frequency analysis (SFA) was applied for image analysis as a better method capable of evaluating the apparent age. Firstly the estimated facial age obtained from SFA indicated high correlation (R2=0.893) with chronological age. Next, cluster analysis of the RGB and gray power values obtained from SFA were carried out in order to classify the characteristic frequency. As the result, the power value was classified into five domains that corresponded to the each skin feature, such as brightness and texture. Estimated age obtained from each domain showed differences among subjects in spite of the same age. Finally in order to confirm whether the developed method is suitable for the evaluation of effectiveness of anti-aging cosmetics, the estimated age and that obtained from each domain were evaluated with and without makeup treatment.
These results indicated that this method may be applicable to the evaluation method for measuring the effectiveness of anti-aging cosmetics. In conclusion, our developed method using SFA suggests that it is more accurate and useful for assessing the apparent age, and it provides crucial information to understanding the effectiveness of anti-aging cosmetics.


Dermatological R&D
Skin Research Department
Akihiro Tada

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